-  Ten women with a diagnosis of vesical instability entered this study, after signing their pertinent informed consent.

-    No patient referred to a history of neurological background, and all of them had previously used anticholinergic, with a partial answer.

-    A filling cystometry was done (Dantec) and we obtained a daily urination immediately before the infusion of the medication, and 30 days after the procedure.
 

RESINIFERATOXIN PREPARATION

- 90ml physiologic serum

-   9,5ml alcohol at 96%

-    0,5ml of stock solution at 10 micromolar of Resiniferatoxin

-  ONLY ONE INSTILLATION, INTRAVESICAL,  WITH A SOLUTION OF 50nm OF RESINIFERATOXIN, 30 MINUTES